|
KMID : 0984920180200020063
|
|
Journal of Skin Barrier Research
2018 Volume.20 No. 2 p.63 ~ p.63
|
|
|
Stem Cell-derived Exosome and Dermatitis
|
|
Kim Jin-Ok
|
|
|
Abstract
|
|
|
|
Exosome is nano-size vesicle (30-200 nm) released by almost all cells, and found in all body fluids. Exosome delivers its cargos, such as proteins, lipids, and nucleic acids, between cells to transfer information from originating cells to recipient cells. These make exosome, especially derived from stem cell, a promising cell-free therapy option to treat multiple diseases through overcoming drawbacks of cell-based therapy while recapitulating the function of stem cell such as repair and regeneration. In the present study, we investigated the effect of human adipose tissue-derived mesenchymal stem cell exosome (ASC-EXOSOME) on dermatitis in animal models. ASC-Exosomes were isolated from the serum-free conditioned media by sequential filtration and characterized as recommended by the International Society for Extracellular Vesicles (ISEV). The effect of ASC-EXOSOME on dermatitis was analysed in two different murine models.
|
|
|
KEYWORD
|
|
|
adipose tissue-derived mesenchymal stem cell (ASC), exosome, dermatitis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|